PN - Androdex
Androdex™ Liquid Prohormone
Androdex is the new and high-powered triple-ingredient combo from Platinum Nutra. It is designed to enhance gains in muscular size while modulating the negative expression of cortisol. This makes Androdex an ideal choice for natural athletes interested in clean, lean bulking. Because of its strong anabolic potential, and reduced tendency toward bloat and fat gain, it's also very well suited for maintaining muscle on a cut.
5-Androsten-3b-ol-17-one (Dehydroepiandrosterone / DHEA)
Versatile Corticometric Steroid Hormone
DHEA is a natural steroid hormone which is biosynthesized predominately in the adrenals. Blood levels are relatively high in adolescence but begin to decline rapidly in young adulthood. It is commonly used to promote bone density, support lean muscle mass and hardness, alleviate depression, encourage libido, improve immune function, and sooth inflammatory conditions without the need for catabolic corticoids. Decades of research are available to support the utility of DHEA in these applications, and all these applications can be particularly pertinent to athletes. For example, supraphysiological doses of DHEA increase serum levels of several anabolic androgens. These androgens include the once popular but now scheduled steroid Androstenedione, and conjugated metabolites of DHT like Androsterone. However, concentrations of undesirable hormones like Cortisol and Aldosterone appear unaffected by DHEA administration.
But what about estrogen? Most bros on the internet say DHEA is estrogenic!
In reality, increases in estrogen (E1 and E2), DHT and Testosterone are statistically non-existent, except in women where Testosterone levels can be significantly elevated over their already low baseline.
How can it be that DHEA possesses all these positive attributes with high oral dosing, but doesn't suppress adrenal or testicular axis?
To understand this, we must turn to the field of Endocrinology known as Intracrinology. Basically, all enzymes needed to convert DHEA into androgens are expressed in a cell-specific fashion in the peripheral target tissues. This allows the androgen-sensitive tissues like muscle to use DHEA locally, and control the intracellular concentrations of these newly formed androgens on-site. This means that oral supplementation with exogenous DHEA enables regulated production of androgens, only in appropriate target tissues, without leakage of significant amounts of metabolites into the general circulation. This local/intracrine action minimizes the inappropriate exposure of other tissues to androgens, virtually eliminating the risk of undesirable systemic effects such as testicular shut-down.
But besides the utility of DHEA as an androgen precursor in target tissue, research has also noted an inverse relationship between cardiovascular mortality and plasma DHEA levels in men. This anti-atherogenic action, and reduction in vascular dysfunction is very intriguing. It is commonly believed that estrogen is "heart-healthy" but that androgens are not, so how can this be? In endothelial cells, DHEA is demonstrated to increase the expression of nitric oxide synthase (NOS) and the subsequent secretion of nitric oxide (NO), which is commonly known to regulate the vascular system in a positive way for athletes. NO products are quite abundant these days, and everyone seems to love the pump that NO boosters provide, but DHEA has it all. It offers the positive cardiovascular pump and skeletal benefits of estrogens, plus the muscle-enhancing properties of androgens, without the elevated blood levels or side effects of either.
DHEA is also generally observed to decrease Sex Hormone-Binding Globulin (SHBG) and increase IGF-1 levels in the blood. These are both highly desirable effects because they discourage feedback suppression and promote additional growth. Another encouraging observation is that hCG treatment increases intratesticular DHEA concentrations. This makes a strong argument for the steroidogenic action of DHEA, rather than any suppressive potential, but this is not yet fully characterized. In addition to these peripheral steroidogenic effects, DHEA may also promote central steroidogenic processes by interaction with the NMDA receptor. This is only speculation because LH studies with consistent results in healthy men are hard to find.
So what's the practical potential of DHEA?
In the gym (real world) DHEA can be expected to promote muscular density and hardness after just a few days of use. This rapid response seems related to its notable insulinomimetic activity, which is crucial to the anabolic effect of androgens. It also works well in practically any stack, and doesn't induce any discernable estrogenic or corticogenic sides. On paper, HPTA suppression may be possible. However, it has never actually been observed by this author in himself or any other athlete and is therefore considered extremely unlikely.
Anabolic Adrenal Metabolite
Epiandrosterone is a precursor to DHT (aka: Stanolone) which is the primary androgen in men, and quite potent. By virtue of its reduced structure, it does not aromatize into estrogen, so side effects like gyno, water retention, etc.. are rarely encountered. It is particularly effective at promoting strength and increasing muscular definition.
Epiandrosterone is estimated to be only about 2% as androgenic as Testosterone, so it's not too surprising that its HPTA suppressive potential is low. However, some of its metabolites are distinctly suppressive, so extended use should be terminated with a ramp-down at minimum, or more appropriately with a proper PCT to guard against post-cycle complications.
Potent Androgen and Pheromone
Androsterone retains about 15% of Testosterone's androgenicity, so while it is somewhat similar to Epiandrosterone in structure, it is considerably more virilizing qualitatively. It's decidedly more potent quantitatively as well, and this makes it an excellent pre-workout or pre-competition addition to enhance alpha attitude and competitive aggression. This sensation is commonly referred to as feeling "on" and Androsterone delivers it.
Androsterone blood levels and ratios are also a prominent marker for sexual preference, with high Androsterone levels corresponding to a stronger desire for women. Men with high Androsterone levels are also perceived more positively by women, who tend to view them as trusted alpha types.
There are several Androsterone derived steroid esters available on the market today, usually labeled erroneously as "DHEA" with a number next to it, but don't be fooled. None of them share the potency or benefit of real Androsterone.